Table 1.

Chemo-informatics characteristic of the newly synthesized compounds 2a–2f

Properties	2a	2b	2c	2d	2e	2f	Standard
M.Wt. (g/mol)	372.09	346.09	400.14	324.09	362.09	360.09	< 500
HBA	5	3	5	4	4	4	< 10
HBD	1	1	1	1	1	1	< 5
Log P	3.70	4.22	4.74	3.78	4.41	4.53	< 5
PSA (A2)	59.85	45.29	59.75	45.29	51.23	46.04	< 89
nrotb	5	4	6	4	5	4	< 10
Drug Score	0.31	− 0.04	0.50	0.38	0.45	0.61	0.0–2.0