Table 2.

Combination of apple pectins with SN-38 against colon cancer cell growth.

Cell Line	Concentration (mg/mL)			Ratio	Combination Index (CI)
	SN-38	PX	PCX
	0.78 × 10−6	0.1	-	128,200:1	0.629
	1.96 × 10−6	0.2	-	102,000:1	0.863
HCT 116	3.14 × 10−6	0.5	-	157,730:1	1.010
	0.78 × 10−6	-	0.1	128,200:1	0.543
	1.96 × 10−6	-	0.2	102,000:1	0.561
	3.14 × 10−6	-	0.5	157,730:1	0.905
	0.78 × 10−6	0.1	-	128,200:1	0.895
	1.96 × 10−6	0.2	-	102,000:1	0.791
	3.14 × 10−6	0.5	-	157,730:1	0.821
Caco-2
	0.78 × 10−6	-	0.1	128,200:1	0.599
	1.96 × 10−6	-	0.2	102,000:1	0.424
	3.14 × 10−6	-	0.5	157,730:1	0.489
	0.78 × 10−6	0.1	-	128,200:1	0.725
	1.96 × 10−6	0.2	-	102,000:1	0.726
	3.14 × 10−6	0.5	-	157,730:1	0.735
HT-29
	0.78 × 10−6	-	0.1	128,200:1	0.822
	1.96 × 10−6	-	0.2	102,000:1	0.941
	3.14 × 10−6	-	0.5	157,730:1	0.956

Dose and effect data were obtained from the MTT assay (mean values of three experiments) and analyzed by CompuSyn software. CI values were calculated by CompuSyn software. CI = 1 indicates additive effect, CI < 1—synergism, and CI > 1—antagonism.