Table 3.
Relative caspase-3 activity in colon cancer cells treated with pectins (at 0.2 mg/mL) and pectins in combination with SN-38 (at 5 nM) for 48 h.
| Cell Line | Pectin (mg/mL) | Relative Caspase-3 Activity | |
|---|---|---|---|
| +5 nM SN-38 | |||
| HCT 116 | 0 | 1.00 ± 0.00 | 1.06 ± 0.06 |
| 0.2 PX | 1.40 ± 0.06 * | 2.36 ± 0.04 * § | |
| 0.2 PCX | 1.47 ± 0.03 * | 2.43 ± 0.02 * § | |
| Caco-2 | 0 | 1.00 ± 0.00 | 1.08 ± 0.01 |
| 0.2 PX | 1.59 ± 0.05 * | 2.40 ± 0.00 * § | |
| 0.2 PCX | 1.69 ± 0.02 * | 2.63 ± 0.02 * § | |
| HT-29 | 0 | 1.00 ± 0.00 | 1.18 ± 0.19 |
| 0.2 PX | 1.59 ± 0.01 * | 2.55 ± 0.08 * § | |
| 0.2 PCX | 1.67 ± 0.03 * | 2.76 ± 0.25 * | |
The means of three experiments ± SD are presented (* p < 0.05). Statistical significance was checked between the studied probes and controls (no pectin), and between the probes containing only pectin and pectin together with SN-38 (§ p < 0.05).