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. Author manuscript; available in PMC: 2022 Jun 24.
Published in final edited form as: J Nat Prod. 2020 Nov 23;84(3):750–761. doi: 10.1021/acs.jnatprod.0c00946

Figure 3.

Figure 3.

Detection of groove-binding agents bisbenzimide (5) and neomycin (6) and covalent-binding compounds melphalan (7) and carmustine (8) using LLAMAS. Compounds 5, 7, and 8 were observed by UV (λ 254 nm) detection, whereas 6, which lacks a suitable UV chromophore, was monitored using the MS EIC trace. Individual plots show the peak areas for the compounds in the filtrate of the control group (incubated without DNA) superimposed on the traces recorded for the experimental samples (incubated with DNA) (NL: normalized intensity; EIC: extracted-ion chromatogram).