Figure 5.

Detection of DNA-binding agents incorporated into a complex soil extract using LLAMAS. DNA intercalators 1 and 2 were added to an organic extract of soil (1:1:600, w/w/w). (A) UV chromatograms (λ 254 nm) revealed test compounds were detectable based on comparisons of samples incubated with and without DNA (upper trace) and after dissociation (lower trace). (B) Similarly, the EIC traces demonstrated that mass-spectrometry-based detection could also serve as a suitable tool for compound detection when dealing with complex chemical mixtures (NL: normalized intensity; RT: retention time).