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. Author manuscript; available in PMC: 2022 Jun 24.
Published in final edited form as: J Nat Prod. 2020 Nov 23;84(3):750–761. doi: 10.1021/acs.jnatprod.0c00946

Figure 6.

Figure 6.

Identification of the DNA-binding natural products actinomycin D (9), V (10), and X0β (11) from S. antibioticus using LLAMAS. (A) Analysis of the PDA chromatogram (λ 190–602 nm) revealed putative DNA-binding substances in the bacterial extract (candidate DNA-binding compounds are highlighted in red). (B) By focusing on these regions of interest, the MS data revealed evidence for three suspected DNA-binding agents in the extract: 9 (tR = 8.64 min, [M + H]+ ion at m/z 1255.75), 10 (tR = 8.64 min, [M + H]+ ion at m/z 1269.67), and 11 (tR = 7.77 min, [M + H]+ ion at m/z 1271.75).