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. Author manuscript; available in PMC: 2022 Jun 24.
Published in final edited form as: J Nat Prod. 2020 Nov 23;84(3):750–761. doi: 10.1021/acs.jnatprod.0c00946

Table 1.

DNA Binders 1–8 Used for Method Development

Name Structure Binding mechanism Solubility in aqueous solution Distinct UV absorbance Theoretical m/z in MS
9-aminoacridine (1) graphic file with name nihms-1810612-t0012.jpg intercalator poor yes 195.09
ellipticine (2) graphic file with name nihms-1810612-t0013.jpg intercalator poor yes 247.12
methapyrilene (3) graphic file with name nihms-1810612-t0014.jpg intercalator poor yes 262.14
chlorpheniramine (4) graphic file with name nihms-1810612-t0015.jpg intercalator good yes 275.13
bisenzimide (H 33258) (5) graphic file with name nihms-1810612-t0016.jpg groove binder poor yes 425.21
neomycin (6) graphic file with name nihms-1810612-t0017.jpg groove binder good N/A 615.32
melphalan (7) graphic file with name nihms-1810612-t0018.jpg covalent binder poor yes 305.08
carmustine (8) graphic file with name nihms-1810612-t0019.jpg covalent binder poor yes N/A