Table 2.
GI50, TGI, and LC50 Values of Compounds in Cancer Cellsa
| compound | HCC1937 | MDA-MB-453 | MDA-MB-231 | A-673 | SJCRH30 | HCC 1806 | HCC70 | |
|---|---|---|---|---|---|---|---|---|
| cepharanthine | GI50 | 6.0 ± 0.3 | 5.5 ± 0.2 | 5.3 ± 0.1 | 4.5 ± 0.08 | 3.8 ± 0.2 | 7.2 ± 0.1 | 5.8 ± 0.03 |
| TGI | 14 ± 0.9 | 7.8 ± 0.2 | 7.7 ± 0.3 | 5.8 ± 0.08 | 5.7 ± 0.1 | 12 ± 0.5 | 9.6 ± 0.1 | |
| LC50 | 27 ± 2 | 11 ± 0.4 | 12 ± 0.6 | 7.5 ± 0.1 | 8.4 ± 0.2 | 19 ± 1 | 17 ± 0.2 | |
| daurisoline (17) | GI50 | 6.9 ± 0.1 | 9.0 ± 0.2 | 13 ± 0.3 | 9.2 ± 0.03 | 3.7 ± 0.2 | 17 ± 0.3 | 8.8 ± 0.02 |
| TGI | 11 ± 0.2 | 14 ± 0.4 | 19 ± 0.1 | 13 ± 0.6 | 6.0 ± 0.2 | 27 ± 0.7 | 13 ± 0.4 | |
| LC50 | 18 ± 0.7 | 21 ± 1 | 30 ± 0.8 | 19 ± 2 | 9.7 ± 0.1 | 41 ± 2 | 19 ± 1 | |
| tetrandrine (16) | GI50 | 4.2 ± 0.07 | 3.3 ± 0.1 | 5.0 ± 0.09 | 4.0 ± 0.3 | 3.0 ± 0.03 | 5.1 ± 0.1 | 3.4 ± 0.1 |
| TGI | 10 ± 0.2 | 4.8 ± 0.1 | 7.4 ± 0.07 | 6.0 ± 0.3 | 4.3 ± 0.04 | 8.5 ± 0.3 | 5.9 ± 0.3 | |
| LC50 | 21 ± 1 | 7.1 ± 0.2 | 12 ± 0.7 | 8.9 ± 0.2 | 6.1 ± 0.06 | 15 ± 1 | 11 ± 0.6 | |
a
GI50, TGI, and LC50 concentrations and standard error of mean (SEM) are reported in μM, n = 3, 4.