Table 3.
Effect of chitosan hydrochloride or carboxymethyl chitosan addition on particle size, zeta-potential, and poly dispersity index (PDI) of hybrid NPs formulated by the w/o/w double emulsion method (mean ± SD, n = 3).
| Chitosan Hydrochloride (1 mg/mL) | Carboxymethyl Chitosan * | |||||
|---|---|---|---|---|---|---|
| Size (nm) | Charge (mV) | PDI | Size (nm) | Charge (mV) | PDI | |
| PGA-co-PDL | 291.0 ± 9.2 | 17.4 ± 1.0 | 0.09 ± 0.04 | 280.5 ± 8.8 | −20.1 ± 1.5 | 0.13 ± 0.02 |
| PLGA | 310.2 ± 6.0 | 13.2 ± 0.8 | 0.10 ± 0.03 | 299.4 ± 7.1 | −40.5 ± 0.9 | 0.09 ± 0.07 |
* Carboxymethyl chitosan 1 mg/mL for PGA-co-PDL formulation and 0.5 mg/mL for PLGA formulation.