TABLE 4.

Inhibitory spectrum of reutericyclin

Organism	Strain designation	Strain properties (reference)	MIC (mg/liter) (n)a
B. cereus	DSM345		0.19 ± 0.04 (2)
B. subtilis	DSM347		0.13 ± 0.003 (2)
B. subtilis	DSM10		0.26 ± 0.02 (2)
B. subtilis	FAD109	Rope formation in bread (43)	0.14 ± 0.02 (6)
B. subtilis	FAD109	Spore formation	0.23 ± 0.02 (4)
B. subtilis	FAD11/2	Rope formation in bread (43)	0.28 (1)
B. subtilis	FAD77	Rope formation in bread (43)	0.26 (1)
B. subtilis	FAD94	Rope formation in bread (43)	0.22 (1)
B. subtilis	FAD97	Rope formation in bread (43)	0.30 (1)
B. subtilis	FAD99	Rope formation in bread (43)	0.31 (1)
E. coli	LTH1600		>100 (4)
E. coli	LTH4346	O157:H7b EHEC	>100 (4)
E. coli	ATCC27325	K-12b	>100 (1)
E. coli	WBB06	Reb (7)	12 (1)
E. coli	F492	O8b (47)	>100 (1)
E. coli	F470	R1b (47)	13 (1)
E. coli	F515	Reb (47)	17 (1)
E. faecalis	DSM20409		0.06 ± 0.01 (3)
E. faecium	DSM20477		0.10 ± 0.02 (3)
E. faecium	70/90	Antibiotic-resistant clinical isolatec	0.16 (1)
E. faecium	1528	Antibiotic-resistant clinical isolatec	0.08 (1)
L. brevis	DSM0054		0.36 (1)
L. buchneri	LTH2162		0.91 (1)
L. buchneri	DSM20057		0.20 (1)
L. casei	LTH2600		0.63 (1)
L. curvatus	LTH1174	Curvacin A producer (55)	0.12 (1)
L. curvatus	LTH1432		0.15 (1)
L. curvatus	DSM20019		0.12 (1)
L. paracasei subsp. paracasei	DSM20312		0.50 (1)
L. plantarum	LTH3904		0.29 (1)
L. plantarum	DSM20174		0.14 (1)
L. pontis	DSM8475	Sourdough (58)	0.10 (1)
L. reuteri	DSM20016		0.09 (1)
L. sakei	LTH673	Sakacin P producer (55)	0.09 (1)
L. sakei	DSM20017		0.11 (1)
L. sanfranciscensis	ATCC27651	Sourdough (34)	0.10 ± 0.02 (6)
L. sanfranciscensis	LTH1729	Sourdough (6)	0.16 (1)
L. sanfranciscensis	LTH4469	Sourdough	0.12 (1)
L. sanfranciscensis	LTH4801	Sourdough	0.18 (1)
Weissella confusa	DSM20196		0.13 (1)
L. reuteri	LTH3569	SERd (5)	0.26 (1)
L. mucosae	LTH3566	SER (5)	0.36 (1)
Lactobacillus sp.	LTH3568	SER (5)	0.59 (1)
Lactobacillus sp.	LTH3578	SER (5)	0.67 (1)
Lactobacillus sp.	LTH3579	SER (5)	0.25 (1)
L. reuteri	LTH2584	SER (5), reutericyclin producer	6.5 ± 1.2 (6)
Listeria innocua	DSM20649		0.19 (1)
Listeria ivanovii	DSM20750		0.12 (1)
S. aureus	DSM20231		0.20 (1)
S. aureus	BB255	Metse	0.26 (1)
S. aureus	RN450	Mets	0.24 (1)
S. aureus	BB270	Metre, derivative of strain BB255	0.21 (1)
S. aureus	SG 511	Mets	0.13 (1)
S. aureus	581/93	Metr	0.21 (1)
S. aureus	COL	Metr	0.20 (1)
Brettanomyces sp.	LTH036		>100 (1)
Candida krusei	LTH062		>100 (1)
Saccharomyces cerevisiae	LTH218		>100 (1)
Saccharomyces cerevisiae	LTH072		>100 (1)

^aMean ± standard deviation of n determinations. The coefficient of variation of the assay system was generally 20% or less. 

^bLPS chemotype. EHEC, enterohemorrhagic E. coli. 

^cResistant to cephalothin, erythromycin, clindamycin, gentamicin, tetracyclin, and vancomycin (G. Reuter, personal communication). 

^dSER, sourdough extract rye (in-house sourdough used for production of a commercial baking aid). 

^eMet^s and Met^r, methicillin sensitive and resistant, respectively. S. aureus data from H. Maidhoff (personal communication).