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. 2022 May 27;14(6):1143. doi: 10.3390/pharmaceutics14061143

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Synergistic effect of ChoKα inhibitors and cisplatin in H460 and H1299 cells. (A,B) H460 cells were exposed to cisplatin for 5 h. Then, cells were treated with RSM-932A/TCD-717 (A) or MN58b (B) for 40 h. Cytotoxicity was evaluated by MTT assay (left panels). Combinations of the two drugs was also tested using flow cytometry analysis (right panels). (C,D) H1299 cells were treated as indicated for H460 cells with either RSM932A/TCD-717 (C) or MN58b (D). Represented CI value in each case is the mean of three independent experiments for each concentration in quadruplicate. As shown for both drugs, a CI < 1 indicated a strong synergistic effect. Furthermore, combination of the two drugs increased cell death compared to the two drugs alone, as determined by flow cytometry analysis. As shown, similar results were obtained with both cell lines.

Synergistic effect of ChoKα inhibitors and cisplatin in H460 and H1299 cells. (A,B) H460 cells were exposed to cisplatin for 5 h. Then, cells were treated with RSM-932A/TCD-717 (A) or MN58b (B) for 40 h. Cytotoxicity was evaluated by MTT assay (left panels). Combinations of the two drugs was also tested using flow cytometry analysis (right panels). (C,D) H1299 cells were treated as indicated for H460 cells with either RSM932A/TCD-717 (C) or MN58b (D). Represented CI value in each case is the mean of three independent experiments for each concentration in quadruplicate. As shown for both drugs, a CI < 1 indicated a strong synergistic effect. Furthermore, combination of the two drugs increased cell death compared to the two drugs alone, as determined by flow cytometry analysis. As shown, similar results were obtained with both cell lines.