Table.
Clinical and Imaging Characteristics
| Characteristics | Persistent Target Mismatch Profile (n=10) | Lost Target Mismatch Profile (n=35) | p-value |
|---|---|---|---|
| Clinical Characteristics | |||
| Median Age (IQR) | 77 (63–84) | 64 (56–74) | 0.08 |
| Female Gender (%) | 50% | 51% | 1.0 |
| Median Baseline NIHSS (IQR) | 13 (8.5–22.5) | 19 (12.5–22.0) | 0.23 |
| Glucose | 111.5 (108.0–124.8) | 128.0 (112.0–151.5) | 0.14 |
| Systolic Blood Pressure | 152.5 (132.5–160.0) | 142.0 (131.0–159.0) | 0.49 |
| Diastolic Blood Pressure | 82.0 (62.5–99.8) |
80.0 (69.5–89.0) | 0.96 |
| Previous Myocardial Infarction | 0% | 9% | 1.0 |
| Hypertension | 80% | 80% | 1.0 |
| Atrial Fibrillation | 30% | 23% | 0.69 |
| Hypercholesterolemia | 30% | 34% | 1.0 |
| Diabetes | 20% | 34% | 0.47 |
| Prior Stroke | 20% | 9% | 0.31 |
| Antiplatelet therapy | 40% | 23% | 0.42 |
| Anticoagulant | 10% | 11% | 1.0 |
| Statin therapy | 20% | 29% | 0.71 |
| Diabetic Medication | 0% | 26% | 0.17 |
| Anti-hypertensive therapy | 70% | 57% | 0.72 |
| Median NIHSS at 24h (IQR) | 14.5 (11.2–24.0) | 17.0 (11.0–20.0) | 0.83 |
| Median mRS at day 90 (IQR) | 5.0 (3.2–6.0) | 4.0 (3.0–4.5) | 0.14 |
| mRS 0–2 at day 90 (%) | 10% | 17% | 1.0 |
| mRS 5–6 at day 90 (%) | 60% | 26% | 0.06 |
| Baseline Imaging Characteristics | |||
| Core volume, ml (IQR) | 7 (3–12) | 17 (3–34) | 0.17 |
| Tmax>6s volume, ml (IQR) | 98 (66–137) | 110 (76–157) | 0.48 |
| Tmax>10s volume, ml (IQR) | 18 (4–50) | 42 (17–80) | 0.07 |
| Mismatch volume, ml (IQR) | 92 (62–131) | 88 (59–129) | 0.83 |
| Hypoperfusion intensity ratio* (IQR) | 0.20 (0.04–0.35) | 0.38 (0.24–0.56) | <0.01 |
| Percent MCA occlusions | 60% | 57% | 1.0 |
| Percent ICA occlusions | 40% | 43% | 1.0 |
| 24-hour imaging characteristics | |||
| Last well to 24h post-randomization imaging, hrs (IQR) | 38.4 (37.8–39.1) | 36.5 (32.7–39.3) | 0.25 |
| DWI volume, 24h post-randomization, ml (IQR) | 23 (11–31) | 88 (34–134) | <0.001 |
| Tmax>6s volume, 24 h post-randomization ml (IQR) | 77 (60–91) | 47 (24–75) | <0.05 |
| Infarct growth baseline to 24h, ml (IQR) | 15 (8–21) | 59 (22–110) | <0.001 |
| Change in Tmax>6s volume, baseline to 24h, ml (IQR) | -34 (−60–5) | -49 (−94- −17) | 0.33 |
| Percent reperfusion (IQR) | 30% (10%−−40%) | 50% (20%- 80%) | 0.02 |
| Mismatch volume ml (IQR) | 50 (38–80) | -19 (−82–0) | <0.001 |