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The proposed signaling pathways involved in the role of extracellular vesicles, miR-138-5p, GPR124, and NLRP3 inflammasome in normal early pregnancy and spontaneous miscarriage. These results demonstrate an important function for mi138-5p in regulating the embryo implantation and early pregnancy, through the modulation of GPR124, and the following activation of inflammasome NLRP3, IL-18, and IL-1β signalings.
