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. 2022 Jun 10;8(4):e109. doi: 10.1192/bjo.2022.65

Table 3.

Script-elicited brain activity in 51 female patients with post-traumatic stress disorder

x y z t P(FWE) k AAL Hemisphere
Brain activation clusters during traumatic > neutral recall
−6 −70 −25 7.24 P < 0.001 4185 Lobule VI of cerebellar hemisphere Left
−45 −76 −7 7.18 P < 0.001 Inferior occipital gyrus Left
0 −61 −28 7.08 P < 0.001 Lobule VIII of vermis
−60 −43 32 5.97 P = 0.006 74 Supramarginal gyrus Left
−57 −34 23 5.69 P = 0.015 Supramarginal gyrus Left
−57 −31 32 5.48 P = 0.028 Supramarginal gyrus Left
Brain activation clusters during traumatic > neutral retrieval
−45 −82 8 8.21 P < 0.001 8863 Middle Occipital gyrus Left
−54 −64 11 8.19 P < 0.001 Middle Temporal gyrus Left
−60 −58 5 8.09 P < 0.001 Middle Temporal gyrus Left
60 −40 26 6.75 P < 0.001 1031 Supramarginal gyrus Right
−3 −28 −7 6.74 P < 0.001 Dorsal raphe nucleus
63 −28 35 6.68 P = 0.001 Supramarginal gyrus Right
9 5 50 5.87 P =0.009 61 Supplementary motor area Right
−6 8 41 5.70 P = 0.014 Middle cingulate and paracingulate gyri Left
9 11 38 5.54 P = 0.023 Middle cingulate and paracingulate gyri Right
3 −1 62 5.86 P = 0.009 52 Supplementary motor area Right
−6 −7 68 5.66 P = 0.016 Supplementary motor area Left
9 −7 65 5.50 P = 0.026 Supplementary motor area Right
21 −1 −1 5.78 P = 0.011 140 Pallidum Right
42 5 11 5.71 P = 0.014 Rolandic operculum Right
45 14 11 5.67 P = 0.016 Inferior frontal gyrus, opercular part Right
36 11 26 5.76 P = 0.012 39 Inferior frontal gyrus, opercular part Right
−33 11 11 5.39 P = 0.036 13 Insula Left
−39 2 8 5.35 P = 0.041 Insula Left
Brain activation clusters during traumatic > neutral re-experiencing

Coordinates (in Montréal Neurological Institute space) and anatomical labels (AAL) for overactivations in patients with post-traumatic stress disorder (PTSD) during the traumatic (versus neutral) memory (a) recall, and (b) retrieval during script presentation; and (c) re-experiencing during imagery (no statistically relevant findings) for a family-wise error (FWE)-corrected threshold of PProbabilistic threshold-free cluster enhancement < 0.05, with cluster extent threshold of k ≥ 10.