Table 2.
Cross-reactivity of the single-round infection fluorescent SARS-CoV-2 virus (ΔORF3–E mNG SARS-CoV-2) neutralization test (SFVNT).
| a Immune Sera and b Interfering Substances | Sample Number | Number of SFVNT-Positive |
|---|---|---|
| Adenovirus | 1 | 0 |
| Cryptococcus neoformans antigen | 1 | 0 |
| Anti-cytomegalovirus | 10 | 0 |
| Anti-Epstein–Barr virus capsid or nuclear antigen | 15 | 0 |
| Anti-hepatitis A virus | 9 | 0 |
| Anti-hepatitis B virus surface or core antigen | 21 | 0 |
| Anti-hepatitis C virus | 7 | 0 |
| Anti-herpes simplex virus 1 | 8 | 0 |
| Anti-herpes simplex virus 2 | 3 | 0 |
| Human coronavirus 229E | 1 | 0 |
| Human coronavirus HKU1 | 2 | 0 |
| Human coronavirus NL63 | 1 | 0 |
| Human coronavirus OC43 | 3 | 0 |
| Anti-human immunodeficiency virus 1 | 4 | 0 |
| Human rhinovirus | 2 | 0 |
| Influenza B virus | 1 | 0 |
| Anti-measles virus | 2 | 0 |
| Anti-mumps virus | 1 | 0 |
| Respiratory syncytial virus | 1 | 0 |
| Anti-rubella virus | 16 | 0 |
| Anti-varicella zoster virus | 20 | 0 |
| Anti-West Nile virus | 5 | 0 |
| Anti-yellow fever virus (vaccination) | 1 | 0 |
| b Albumin (4.5–4.9 g/dL) | 7 | 0 |
| b Elevated total bilirubin (1.1 mg/dL) | 5 | 0 |
| b Elevated cholesterol (>200 mg/dL) | 3 | 0 |
| b Elevated rheumatoid factor (>100 IU/mL) | 4 | 0 |
| b Anti-cardiolipin | 2 | 0 |
| b Anti-mitochondrial M2 | 1 | 0 |
| b Anti-nuclear antibodies | 10 | 0 |
a A total of 135 serum/plasma specimens with antigens or antibodies against different infections (or immunizations) were tested against the SFVNT. They are listed in alphabetical order. Samples that tested positive for antibodies against specific pathogens are indicated with the prefix “anti”, whereas samples that tested positive for antigens or pathogen nucleic acids are not indicated with a prefix. For the latter group, the specimens were collected within 1 to 6 months after they PCR tested positive for pathogens. b A total of 32 samples tested for interfering substances, antibodies for active syphilis, and some autoimmune diseases.