Table 1.
The relative abundance (% of the PC, PE or PS) and percentage of change (% change) of the membrane phospholipids that changed in the cerebellum and motor cortex between the ages of 20 and 100 years.
| Fatty Acid Combinations | Microsomal | Mitochondrial | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Cerebellum | Motor Cortex | Cerebellum | Motor Cortex | |||||||
| % of the PC, PE or PS | % Change | % of the PC, PE or PS | % Change | % of the PC, PE or PS | % Change | % of the PC, PE or PS | % Change | |||
| Increase | PC | 14:0_16:0 | - | - | 1.42 ± 0.02 | 15% | - | - | ||
| 16:0_16:0 | 13.55 ± 0.31 | 30% | - | - | - | |||||
| 16:0_18:2 | 1.18 ± 0.05 | 54% | 1.25 ± 0.05 | 51% | 1.10 ± 0.05 | 39% | 1.26 ± 0.05 | 59% | ||
| 16:0_22:6 | - | 4.00 ± 0.03 | 20% | - | ||||||
| PE | 16:0_22:6 | 6.21 ± 0.11 | 25% | 6.27 ± 0.12 | 34% | - | ||||
| 18:0_22:6 | 29.27 ± 0.56 | 20% | 29.54 ± 0.56 | 21% | - | |||||
| 18:1_22:6 | 2.86 ± 0.05 | 26% | 2.95 ± 0.07 | 33% | - | |||||
| 15:0_22:4/ O-16:0_22:4 |
- | 0.65 ± 0.07 | 86% | - | ||||||
| 15:0_22:6/ O-16:0_22:6 |
1.66 ± 0.09 | 61% | 0.73 ± 0.06 | 83% | 1.73 ± 0.12 | 263% | - | |||
| O-18:1_22:5 | - | 1.36 ± 0.11 | 75% | - | ||||||
| O-18:1_22:6 | - | 1.99 ± 0.04 | 16% | 2.74 ± 0.06 | 22% | - | ||||
| PS | 18:0_22:6 | 42.91 ± 6.67 | 48% | 42.16 ± 1.22 | 50% | - | ||||
| 18:1_20:1 | 1.89 ± 0.70 | 129% | - | |||||||
| Decrease | PC | Lyso-18:1 | 0.86 ± 0.05 | 10% | - | |||||
| 16:0_20:1 | 1.54 ± 0.22 | 23% | 1.48 ± 0.21 | 27% | ||||||
| 16:0_20:4 | - | - | 3.59 ± 0.10 | 17% | ||||||
| 16:0_22:4 | 2.50 ± 0.07 | 22% | 2.89 ± 0.23 | 25% | 1.95 ± 0.15 | 41% | ||||
| 18:0_18:1 | 7.55 ± 0.17 | 18% | - | - | ||||||
| 18:0_20:4 | - | - | 1.71 ± 0.08 | 28% | - | - | ||||
| 18:1_22:6 | 1.12 ± 0.03 | 59% | - | - | ||||||
| PE | Lyso 22:4 | 0.51 ± 0.03 | 38% | - | ||||||
| 16:0_22:4 | 0.78 ± 0.04 | 38% | - | - | ||||||
| 18:0_18:1 | 2.83 ± 0.08 | 27% | 2.79 ± 0.08 | 28% | - | |||||
| 18:0_20:4 | 15.97 ± 0.26 | 16% | 16.71 ± 0.38 | 25% | - | |||||
| 18:0_22:4 | 3.49 ± 0.14 | 36% | 3.36 ± 0.13 | 39% | - | |||||
| O-16:1_22:4 | - | 0.52 ± 0.03 | 45% | - | - | |||||
| O-16:1_22:5 | 1.09 ± 0.07 | 54% | - | |||||||
| 17:0_22:4/ O-18:0_22:4 |
1.31 ± 0.07 | 40% | - | |||||||
| PS | 18:0_18:1 | 29.88 ± 6.85 | 38% | - | 28.84 ± 1.06 | 30% | - | |||
| 18:0_20:1 | 2.13 ± 1.13 | 56% | - | - | - | |||||
| 18:0_20:2 | 1.10 ± 0.65 | 38% | - | - | - | |||||
| 18:0_22:4 | 6.12 ± 1.64 | 28% | - | 6.25 ± 0.23 | 37% | - | ||||
Brains were obtained from subjects aged 18 to 104 years, but the comparative analysis was based on the differences between the ages of 20 and 100 years (adjusted for gender). The % of the PC, PE or PS refers to the average percent abundance of each phospholipid molecule within each phospholipid class. % change refers to the percentage change each phospholipid molecule underwent between ages 20 and 100 years. All values are means across the cohort ± SEM. (-) indicates phospholipid not present in that particular membrane fraction.