Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Chemoenzymatic oxidation of ortho-dibromobenzene (13) and synthesis of the functionalized oxazine (21). Reagents and conditions: i. toluene dioxygenase in E. coli JM109 (pDTG601A), 35 °C (87%, 2.4 g/L); ii. 2,2-DMP, pTsOH then NaIO4, CbzNHOH, MeOH, H2O, 0 °C to rt (74% yield).
