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. 2022 Jun 14;27(12):3809. doi: 10.3390/molecules27123809

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Scheme 4 — Elaboration of the C-ring at C-1 via a Pd-catalyzed carbonylation. Reagents and conditions: i. Al(Hg), THF/H₂O (10:1), 0 °C (40% yield); ii. TBSCl, imidazole, DCM, reflux (86% yield); iii. CO, Pd(PPh₃)₄, Et₃N, DMF:MeOH (1:1), 65 °C (54% yield); iv. Et₃SiH, PdCl₂, Et₃N, DCM, rt (not purified).