Table 2.
Comparison of the main features of mGWAS-Explorer with other web-based tools. Symbols used for feature evaluations with ‘√’ for present, ‘−’ for absent, and ‘+’ for a more quantitative assessment (more ‘+’ symbols indicate better support).
| Tool Name | mGWAS-Explorer | Metabolomics GWAS Server | PheWeb | NETMAGE | GePhEx |
|---|---|---|---|---|---|
| Data input and processing | |||||
| SNP | √ | √ | √ | √ | √ |
| LD proxy search | √ | √ | − | − | √ |
| Gene | √ | √ | √ | − | √ |
| Metabolite | √ | √ | √ | − | √ |
| Enrichment analysis | |||||
| SNP-set | √ | − | − | − | − |
| Gene-set | √ | − | − | − | √ |
| Metabolite-set | √ | − | − | − | − |
| Cross-phenotype exploration | √ | √ | √ | √ | √ |
| Visual analytics | |||||
| Network visualization | +++ | − | − | + | − |
| Network customization | +++ | − | − | + | − |
| Integration with PPI network | √ | − | − | − | − |
| Subnetwork extraction | √ | − | − | √ | − |
| Topology-based filtering | √ | − | − | − | − |
| 3D Manhattan plot | √ | − | − | − | − |