Table 5.
Meta-analyses of fish and ω3 fatty-acid intake and breast cancer risk according to re-analyses of [7].
| Type of Studies | Type of ω-3 Fatty Acid Intake | Number of Cases | Relative Risk 50% CI |
p Value |
|---|---|---|---|---|
| Nest CC, CC, cohort | Highest marine n-3 PUFA intake | 16,178 | 0.86 (0.78, 0.94) | 0.002 |
| CC, cohort | Marine n-3 PUFA (Diet) | 11,519 | 0.86 (0.76, 0.96) | 0.007 |
| Cohort | Per 0.1 g/d increment of dietary marine n-3 PUFA | 3114 | 0.93 (0.90, 0.97) | 3.89 × 10−4 |
| CC, cohort | Total n-3 PUFA | NR | 0.96 (0.86, 1.07) | 0.43 |
| Cohort | Per 0.1% energy increment of daily dietary marine n-3 PUFA | 6344/288,626 | 0.97 (0.92, 1.02) | 0.22 |
| CC, cohort | Highest dietary fish intake | 13,323/687,770 | 1.03 (0.93, 1.14) | 0.61 |
| CC, cohort | Per 15 g/d increment of fish intake | 13,323/666,400 | 1.00 (0.97, 1.03) | 0.98 |
| CC, cohort | Marine n-3 fatty (EPA) | NR | 0.86 (0.75–1.01) | 0.098 |
| CC, cohort | Marine n-3 fatty (DHA) | NR | 0.89 (0.75, 1.05) | 0.16 |
| CC, cohort | Marine n-3 fatty (DPA) | 4746/284,724 | 0.91 (0.68, 1.22) | 0.54 |
| Cohort | ALA (diet) | 8274/281,756 | 0.98 (0.90–1.06) | 0.56 |
| Cohort | Per 0.1 g/d increment of dietary ALA intake | 6310/190,451 | 1.00 (0.99–1.01) | 0.54 |
| Cohort | Per 0.1% energy increment of daily dietary ALA intake | 5510/171,680 | 1.00 (0.99, 1.01) | 0.96 |
| CC, cohort | ALA (tissue biomarker and diet) | 9296/284,724 | 0.97 (0.90, 1.04) | 0.39 |
CC, case control; NR, not reported; DPA, docosapentaenoic acid; ALA, α-linolenic acid.