Figure 1.

SARS-CoV-2-specific CoV-iSpot responses in HSCT patients and healthy controls before and after the third vaccination. Distribution of (a) IFN-γ, (b) IL-2, and (c) simultaneous IFN-γ and IL-2 CoV-iSpot responses upon stimulation with S pool of wildtype SARS-CoV-2. Please note that the scales differ. Circles indicate data before the third vaccination (red: HSCT, blue: healthy controls), while triangles indicate data after the third vaccination. Responses before and after the third vaccination were compared by two-tailed Mann–Whitney test. Horizontal lines indicate mean values, while error bars indicate the standard deviation. The dotted line represents the zero line. The black horizontal line indicates the cutoff. In panel (c), the continuous line indicates the cutoff for IFN-γ, while the dashed line indicates the cutoff for IL-2.