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. 2022 Jun 9;27(12):3714. doi: 10.3390/molecules27123714

Figure 10.

Figure 10

DS−1 inhibited the phosphorylation of STAT3. (A) U−2OS cells were treated with DS−1 at 0, 2.5, 5.0, and 7.5 µM for 24 h, and the change in IL-6 mRNA was analyzed by RT-PCR and presented in the histogram. (B) U−2 OS cells were treated with DS−1 at 0, 2.5, 5.0, and 7.5 µM for 24 h, and STAT3, pSTAT3, and p53 were analyzed by Western blot. (C) The expression of pSTAT3 is shown in the histogram. (D) The pSTAT3/STAT3 value is shown in the histogram. Values are the average of three independent experiments, * p < 0.05, ** p < 0.01, *** p < 0.005.