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. 2022 Jun 10;14(12):2411. doi: 10.3390/nu14122411

Figure 2.

Figure 2

Alisol B ameliorated NASH in a CDA diet-induced murine model. The therapeutic effects of Alisol B (100 mg/kg, once daily, p.o.) were evaluated in CDA diet-fed mice as described in the Materials and Methods. (A) Body weight and (B) average food intake were measured. (C) H&E staining (200× magnification) and Sirius Red staining (100× magnification) were performed. (D) NAS score, steatosis score, ballooning score, and inflammation score were quantified. (E) Serum AST and (F) ALT levels, (G) liver TG, and (H) hepatic mRNA levels of inflammatory cytokines were measured. (I) Percentage of collagen deposition was calculated. (J) Western blot analysis of hepatic α-SMA and Col-1a1 was conducted and quantified. Data are expressed as mean ± SD, n = 8. # p < 0.05, ## p < 0.01 compared with the normal control group; * p < 0.05, ** p < 0.01 compared with the CDA group.