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. 2022 Jun 2;7(6):89. doi: 10.3390/tropicalmed7060089

Figure 1.

Figure 1

Clustered dendrogram with heatmap analysis, showing the relationship of phenotypic groups associated with AMR among N. gonorrhoeae isolates as determined by Euclidean Distance method. Key: + = positive, (e.g., PPNG+ = Penicillinase producing-N. gonorrhoeae (βeta-lactamase+)), − = negative (e.g., PPNG− = non penicillinase producing-N. gonorrhoeae (βeta-lactamase-ve)), QR = Quinolone resistance (fluoroquinolone resistance of ciprofloxacin and or norfloxacin resistance), [H] = high level resistance (HLR), NG = N. gonorrhoeae, TRNG+ = plasmid mediated tetracycline resistant-N. gonorrhoeae (MIC ≥ 16 µg/mL), NQ = non quinolone resistance (ciprofloxacin susceptible), [L] = low level resistance (LLR) (MIC < 4 to ≥1 µg/mL to ciprofloxacin), TRNG− = non-plasmid mediated tetracycline resistant-N. gonorrhoeae (MIC < 16 µg/mL), M = MDR; Multidrug Resistance, X = XDR; Extensively Drug Resistance, S = susceptible, R = resistant, Cipro = ciprofloxacin, Norf = norfloxacin, Azt = azithromycin, Pen = penicillin, Tetra = tetracycline, Cxt = ceftriaxone, Cxm = cefixime, Cefur = cefuroxime, Spect = spectinomycin, B.lact = βeta-lactamase, N = negative, P = positive, Euclidean Distance (>−5 to >5) = Z-scores (BLUE to RED) were calculated from susceptible to resistant-N. gonorrhoeae isolates, respectively.