Figure 3.

Graphic scheme of pharmacokinetics of phillyrin in vivo. The plasma protein binding rate of phillyrin reached around 60% upon absorption. After absorption, phillyrin was widely distributed in heart, lung, spleen, liver and kidney. In liver, phillyrin underwent extensive hydrolysis and sulfation catalyzed by enzymes such as SULT1A1 and UGT1A8. Most of the parent component and its metabolites were mainly secreted via urine. SULT1A1: sulfotransferase 1A1, UGT1A8: UDP-glucuronosyltransferase 1A8. (This figure was created with Biorender.)