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. 2022 Jun 10;12:845936. doi: 10.3389/fonc.2022.845936

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Copyright © 2022 Barco, Lavarello, Cangelosi, Morini, Eva, Oneto, Uva, Tripodi, Garaventa, Conte, Petretto and Cangemi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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3-O-Methyldopa expression cutoff visualization. (A) Scatter plot reporting 3-O-Methyldopa expression in 122 NB patients. Cutoff, selected by the Elbow method, is reported within the plot. The relative rank position of the cutoff is shown by a red arrow. (B) Boxplot displaying the low or high 3-O-Methyldopa expression in 122 NB patients according to the cutoff value. Boxplot was visualized using Tukey’s method. Significance of the expression difference between low and high 3-O-Methyldopa expression was carried out by unpaired student’s t test. P value is reported on top of the panel.