Table 2.
Longitudinal assessment of patient frontal lobe function and OCD symptomatology
| Scale | Pre-surgical baseline |
6-month follow-up |
1-year follow-up |
2–4-year follow-up |
≥ 5-year follow-up* |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Frontal Systems Behavior Scale (FrSBe) | |||||||||||
| Self | Family | Self | Family | Self | Family | Self | Family | Self | Family | ||
| Total | T-score (mean, SD) | 71.87 (14.50) | 71.07 (17.53) | 60.23 (12.92) | 67.00 (15.54) | 64.80 (16.66) | 62.77 (16.71) | 57.11 (21.31) | 55.00 (16.69) | 67.50 (19.42) | 61.06 (16.80) |
| % elevated (n elevated/total) | 61.3 (19/31) | 57.1 (16/28) | 29.4 (5/17) | 66.7 (8/12) | 53.3 (8/15) | 46.1 (6/13) | 33.3 (3/9) | 30.0 (3/10) | 50.0 (3/6) | 33.3 (3/9) | |
| AP | T-score (mean, SD) | 85.06 (17.32) | 81.36 (18.72) | 76.35 (19.13) | 79.33 (18.72) | 77.13 (24.12) | 73.83 (25.18) | 66.67 (24.66) | 66.80 (21.13) | 73.11 (23.90) | 66.55 (21.73) |
| % elevated (n elevated/total) | 93.5 (29/31) | 78.6 (22/28) | 76.5 (13/17) | 75.0 (9/12) | 66.67 (10/15) | 58.3 (7/12) | 44.44 (4/9) | 40.0 (4/10) | 50.0 (3/6) | 44.4 (4/9) | |
| DI | T-score (mean, SD) | 59.90 (13.85) | 51.46 (14.50) | 48.53 (12.24) | 47.25 (16.44) | 54.37 (14.19) | 47.23 (11.19) | 51.33 (17.58) | 42.20 (8.32) | 57.94 (12.84) | 48.28 (16.55) |
| %elevated (n elevated/total) | 35.4 (11/31) | 10.7 (3/28) | 11.8 (2/17) | 16.7 (2/12) | 31.2 (5/16) | 7.7 (1/13) | 22.2 (2/9) | 0.0 (0/10) | 33.3 (2/6) | 11.1 (1/9) | |
| ED | T-score (mean, SD) | 65.42 (13.46) | 70.29 (17.36) | 56.29 (10.43) | 69.42 (16.63) | 59.06 (12.40) | 61.00 (15.50) | 52.89 (16.26) | 55.60 (18.37) | 64.89 (19.26) | 63.56 (14.24) |
| % elevated (n elevated/total) | 51.6 (16/31) | 60.7 (17/28) | 17.6 (3/17) | 66.7 (8/12) | 37.5 (6/16) | 46.1 (6/13) | 33.3 (3/9) | 40.0 (4/10) | 50.0 (3/6) | 33.3 (3/9) | |
| Wisconsin Card Sorting Test (WCST) | |||||||||||
| PE | Standard score (mean, SD) | 101.31 (21.94) | 104.22 (20.30) | 105.83 (23.68) | 108.25 (27.02) | 99.40 (15.36) | |||||
| % impaired (≤ 2 SD) (n impaired/total) | 5.6 (2/36) | 5.6 (1/17) | 11.1 (2/18) | 8.3 (1/12) | 0.0 (0/10) | ||||||
| LL | Raw score (mean, SD) | −0.80 (2.77) | −0.82 (4.15) | 0.52 (2.08) | −2.00 (4.20) | −1.11 (5.87) | |||||
| Yale-Brown Obsessive Compulsive Scale (Y-BOCS) | |||||||||||
| Total | (mean, SD) | 33.60 (3.93) | 22.68 (7.87) | 18.63 (6.93) | 14.29 (7.78) | 15.55 (10.72) | |||||
| % elevated (total ≥ 28) (n impaired/total) | 94.7 (36/38) | 21.0 (4/19) | 5.3 (1/19) | 0.0 (0/12) | 11.1 (1/9) | ||||||
| Hamilton Depression Rating Scale (HDRS) | |||||||||||
| Total | (mean, SD) | 25.66 (8.25) | 21.06 (11.00) | 16.21 (9.43) | 13.50 (7.20) | 12.78 (10.99) | |||||
| % elevated (total ≥ 20) (n elevated/total) | 78.9 (30/38) | 61.11 (11/18) | 31.6 (6/19) | 25.0 (3/12) | 33.33 (3/9) | ||||||
*
Includes averaged values for 1 patient with multiple assessments in ≥ 5 years.
Note. AP = Apathy, DI = Disinhibition, ED = Executive Dysfunction subscales of the FrSBe; PE = perseverative errors, LL = learning-to-learn on the WCST. Clinical elevation threshold on FrSBe is T-Scores ≥ 65 for total and subscale scores.