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. 2021 Dec 21;12:777670. doi: 10.3389/fphar.2021.777670

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Copyright © 2021 Liu, Cao, Wang, Zhou, Zhang, Wu, Chen, Qiu and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ZWT regulated the phosphatidylinositol 3-kinase (PI3K)/AKT/mTOR and AMPK pathways in CGN. (A,B) The protein blots and quantitative analysis of PI3K, p-AKT, p-AMPK, and p-mTOR in renal tissue. (C,D) The protein blots and quantitative analysis of PI3K, p-AKT, p-AMPK, and p-mTOR in podocytes. The obtained values of PI3K were normalized to GAPDH, p-AKT values were normalized to AKT, p-AMPK values were normalized to AMPK, and p-mTOR values were normalized to mTOR. Data are represented as mean ± SD (n = 3). ^# p < 0.05, ^## p < 0.01 versus normal or control group, *p < 0.05 and **p < 0.01 versus the model group or TNF-α group. The intervention of PI3K inhibitor and agonist against ZWT.