Table 2.
Univariable and multivariable Cox regression analysis of the NK cell marker genes signature in TCGA LUAD cohort.
| Characteristics | Univariable analysis | Multivariable analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P-Value | HR | 95% CI | P-Value | |
| Age | ||||||
| ≤60 | 1.0 (ref) | |||||
| >60 | 1.217 | 0.906–1.635 | 0.192 | |||
| Gender | ||||||
| Female | 1.0 (ref) | |||||
| Male | 1.049 | 0.784–1.405 | 0.747 | |||
| Smoking history | ||||||
| No | 1.0 (ref) | |||||
| Yes | 0.881 | 0.583–1.330 | 0.546 | |||
| T stage | ||||||
| T1 + T2 | 1.0 (ref) | 1.0 (ref) | ||||
| T3 + T4 | 2.298 | 1.568–3.366 | <0.001 | 1.646 | 1.077–2.515 | 0.021 |
| Lymphatic metastasis | ||||||
| No | 1.0 (ref) | 1.0 (ref) | ||||
| Yes | 2.579 | 1.918–3.469 | <0.001 | 1.903 | 1.326–2.733 | <0.001 |
| TNM stage | ||||||
| I + II | 1.0 (ref) | 1.0 (ref) | ||||
| III + V | 2.584 | 1.893–3.527 | <0.001 | 1.337 | 0.885–2.022 | 0.168 |
| EGFR mutation | ||||||
| No | 1.0 (ref) | |||||
| Yes | 1.332 | 0.872–2.035 | 0.185 | |||
| KRAS mutation | ||||||
| No | 1.0 (ref) | |||||
| Yes | 1.068 | 0.764–1.494 | 0.698 | |||
| TP53 mutation | ||||||
| No | 1.0 (ref) | 1.0 (ref) | ||||
| Yes | 1.413 | 1.054–1.893 | 0.021 | 1.152 | 0.851–1.561 | 0.359 |
| Risk score | ||||||
| Low | 1.0 (ref) | 1.0 (ref) | ||||
| High | 2.356 | 1.740–3.190 | <0.001 | 1.889 | 1.373–2.599 | <0.001 |
HR, hazard ratio; CI, confidence interval; ref, reference category.