TABLE 1.

Summary of RNAseq datasets used in this study.

Dataset name	Study	Data type	Brain region	Total individuals	Controls	AD cases	Other
DLPFC	ROS/MAP	Bulk RNAseq	Dorsolateral Prefrontal Cortex	1092	138	285	669
FP	MSBB	Bulk RNAseq	Frontal Pole	134	44	90	0
IFG	MSBB	Bulk RNAseq	Inferior Frontal Gyrus	112	34	78	0
PHG	MSBB	Bulk RNAseq	Parahippocampal Gyrus	104	38	66	0
STG	MSBB	Bulk RNAseq	Superior Temporal Gyrus	117	35	82	0
TCX	Mayo Clinic	Bulk RNAseq	Temporal Cortex	147	67	80	0
Mathys	ROS/MAP	snRNAseq	Dorsolateral Prefrontal Cortex	47	9	16	22
Zhou	ROS/MAP	snRNAseq	Dorsolateral Prefrontal Cortex	32	8	8	16
Cain	ROS/MAP	snRNAseq	Dorsolateral Prefrontal Cortex	24	5	5	14
AIBS snRNAseq	Allen Institute	snRNAseq	Cingulate Gyrus and Medial Temporal Gyrus	3	3	0	0

Counts of individuals include only samples passing Quality Control.Column of individuals denoted as “Other” indicate individuals from the ROS/MAP cohort not meeting either of the defined control or AD case criteria used in mega-analyses of all cohorts.Note that some individuals from the Mount Sinai Brain Bank, MSBB, were sampled multiple times from different brain regions; therefore, not all samples are independent.