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Hyperpolarization-activated proton pore reveals a distinctive VSD activation mechanism. (A) Representative gating current recording for R210H channel under symmetrical pH conditions. (B) External acidification protonates the histidine at this position, forming an inward rectifying proton channel. Error bars = SD. (C) relationship for R210H mutant obtained at symmetrical pH = 7.4. (D) Steady-state current versus voltage curve obtained from current records such as those shown to the left.
