Figure 3: Hemopexin improves exercise tolerance in SCD mice.
(A) Hyperbolic curve fit for critical speed in Hpx treated and untreated SCD mice. (B) Anerobic work capacity demonstrates the liner relationship between exercise intensity vs. . (C) Dose and main effect of Hpx treatment on exercise tolerance as determined from the the quantitative value for critical speed plotted as bar graphs representing animals in each cohort. (D) Dose and main effects of Hpx treatment on the glycolytic state during exercise as quantitatified by the value or slope of the anerobic work capacity. The anerobic work capacity is plotted as a bar graphs representing animals for each cohort. (E) Packed red blood cell volume as measured by the hemotocrit and plotted as bar graphs representing each cohort. (F) High spleen weights associate with red blood hemolysis. Absence any difference in packed red cell volume and spleen weights suggests Hpx therapy is not altering red blood cell oxygen delivery. * p<0.05