Skip to main content
. 2022 Jun 24;17(6):e0268693. doi: 10.1371/journal.pone.0268693

Fig 1. Increased expression of MELK mRNA in Basal-like breast cancer.

Fig 1

(A) Subtype-specific expression of MELK mRNA was identified using RiboZero RNA-sequencing in breast tumors (n = 50) from women of diverse ethnicities including 66% of African Americans (AA). (B). MELK mRNA expression was determined in 45 breast cancer cell lines using the CCLE dataset. (C) MELK1 expression was analyzed using the Pan-Cancer RNA-Seq dataset. The arrow indicates MELK expression from basal-like breast tumors (BRCA-Basal) compared to non-Basal subtypes of breast cancer (BRCA-non-Basal) and other cancers. ACC, Adrenocortical Carcinoma; BLCA, Bladder Urothelial Carcinoma; BRCA, Breast Invasive Carcinoma; CESC, Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma; CHOL, Cholangiocarcinoma; COADREAD, Colon Adenocarcinoma & Rectum Adenocarcinoma; DLBC, Lymphoid Neoplasm Diffuse Large B-cell Lymphoma; ESCA, Esophageal Carcinoma; GBM, Glioblastoma Multiforme; HNSC, Head and Neck Squamous Cell Carcinoma; KICH, Kidney Chromophobe; KIRC, Kidney Renal Clear Cell Carcinoma; KIRP, Kidney Renal Papillary Cell Carcinoma; LAML, Acute Myeloid Leukemia; LGG, Brain Lower Grade Glioma; LIHC, Liver Hepatocellular Carcinoma; LUAD, Lung Adenocarcinoma; LUSC, Lung Squamous Cell Carcinoma; MESO, Mesothelioma; OV, Ovarian Serous Cystadenocarcinoma; PAAD, Pancreatic Adenocarcinoma, PCPG, Pheochromocytoma and Paraganglioma; PRAD, Prostate Adenocarcinoma; SARC, Sarcoma; SKCM, Skin Cutaneous Melanoma; STAD, Stomach Adenocarcinoma; TGCT, Testicular Germ Cell Tumors; THCA, Thyroid Carcinoma; THYM, Thymoma; UCEC, Uterine Corpus Endometrial Carcinoma; UCS, Uterine Carcinosarcoma; UVM, Uveal Melanoma.