Fig 5. Predictions for modification of Cxxx sequences based on various methods.

Predictions for prenylation and cleavage for all 8000 Cxxx sequences (A-C) and 89 naturally occurring yeast Cxxx sequences (D-F). Models used for prenylation prediction were SVM-ESM-1b (A,B,D,E) and the in-house, frequency-based method (C,F). Models used for cleavage prediction were SVM-ESM-1b (A,D) and the in-house, frequency-based method (B,C,E,F). Predictions are binned as non-prenylated (white), shunted (gray), and cleaved sequences (black). Cleaved sequences have a prerequisite of being prenylated by the indicated prediction model.