Table 3.
Endogenous and synthetic inhibitors of ADAMs and ADAMTS.
| Inhibitor | Target | Reference |
|---|---|---|
|
Endogenous: TIMP-1 |
ADAM10, 12, 15, 17 | (Pelisek, et al., 2012; Rapti, et al., 2008) |
| TIMP-2 | ADAM17, 33 ADAMTS1 |
(Kveiborg, et al., 2010) |
| TIMP-3 | ADAM10, 12, 15, 17, 28, 33 ADAMTS1, 2, 4, 5 |
(Bekhouche & Colige, 2015; Kashiwagi, Tortorella, Nagase, & Brew, 2001; Pelisek, et al., 2012; Rapti, et al., 2008; Schubert, et al., 2019; W. M. Wang, et al., 2006) |
| TIMP-4 | ADAM17, 28, 33 | (Heijink, et al., 2011) |
| α−2 macroglobulin | ADAMTS2, 4, 5 | (Bekhouche & Colige, 2015; Tortorella, et al., 2004; W. M. Wang, et al., 2006) |
| Papilin | ADAMTS2 | (Kramerova, et al., 2000) |
|
Synthetic: Batimastat (BB-94) |
ADAM8, 9, 17, MMPs | (Heijink, et al., 2011) |
| BK-1361 inhibitor peptide | ADAM8 | (J. Chen, et al., 2016) |
| Calcium pentosan polysulfate | ADAMTS4, 5 | (Takizawa, et al., 2008; Troeberg, et al., 2008; Vistnes, et al., 2014) |
| CGS27023 | ADAM9, 10, 17 | (Qian, et al., 2002) |
| Cis-1(S)2(R)-amino-2-indanol-based compounds | ADAMTS4, 5 | (Tortorella, et al., 2009) |
| cyclo(RLsKDK) cyclic peptide | ADAM8 | (Yim, et al., 2016) |
| Doxycycline | ADAMTS13, MMPs | (Bartoli, Kang, et al., 2015) |
| FC143, FC387 | ADAM8, 17 | (Schlomann, et al., 2019) |
| GI254023 | ADAM9, 10, 17, MMPs | (P. Zhang, et al., 2016) |
| Glycoconjugated arylsulfonamide | ADAMTS5 | (Santamaria, et al., 2021) |
| GM6001 | ADAM9, MMPs | (Maretzky, et al., 2017) |
| Granulin-epithelin precursor | ADAMTS7, 12 | (Guo, et al., 2010; Kelwick, Desanlis, et al., 2015) |
| GW280264X | ADAM8, 9, 10, 17 | (P. Zhang, et al., 2016) |
| INCB3619 | ADAM8, 9, 10, 17, 33 | (P. Zhang, et al., 2016) |
| KP457 | ADAM10, 17 | (P. Zhang, et al., 2016) |
| α-Lipolic acid | ADAM17 | (de Queiroz, et al., 2015) |
| Marimastat | ADAM9, 17, MMPs | (Maretzky, et al., 2017; Parrish, et al., 2018) |
| Propofol anesthetic | ADAM8 | (X. Yu, Shi, Wang, & Zhang, 2019) |
| TAPI-1 | ADAM17, MMPs | (Moss & Rasmussen, 2007) |
| TAPI-2 | ADAM9, 17, other ADAMs, MMPs | (Moss & Rasmussen, 2007) |