Skip to main content
. 2022 Jun 24;17(6):e0269920. doi: 10.1371/journal.pone.0269920

Fig 4. Urinary excretion of tetrahydrocortisone (THE), α-cortolone and β-cortolone in diabetic patients and healthy controls.

Fig 4

Urinary excretion of the cortisone metabolites THE, α-cortolone and β-cortolone in non-diabetic (n = 155 for men, n = 161 for women) and diabetic patients (n = 21 for men and n = 20 for women) measured by GC-MS. The groups were matched for age and gender. Diabetic women excreted significantly more THE, α-cortolone and β-cortolone as their healthy controls. Men excreted significantly more THE and α-cortolone as healthy controls. There was no significant change in β-cortolone excretion between diabetic and healthy men. A) THE **p = 0.004 (men), ***p<0.0001 (women). B) α-cortolone **p = 0.009 (men), ***p<0.0001 (women). C) β-cortolone ns (men), ***p<0.0001 (women). Kolmogorov-Smirnov test (non-parametric, unpaired). Dot blot is shown with Log (10) scale and steroid concentrations are displayed in ug/24h. White circles = control men, black circles = diabetic men, white squares = control women, black squares = diabetic women. *p<0.05, **p<0.01, ***p<0.0001, ns = not significant.