Table 2. Absolute values of the urinary steroid hormone metabolites of the two human cohorts.
| Mineralocorticoid metabolites | ug/24h | p-value |
|---|---|---|
| mean +/- SEM, n | ||
| TH-Aldo diabetic men | 35.69 ± 6.338, n = 21 | 0.031 |
| TH-Aldo control men | 23.01 ± 1.233, n = 155 | |
| TH-Aldo diabetic women | 35.92 ± 7.428, n = 20 | 0.391 |
| TH-Aldo control women | 23.14 ± 1.529, n = 161 | |
| 18-OH-THA diabetic men | 78.2 ± 15.04, n = 19 | 0.391 |
| 18-OH-THA control men | 69.2 ± 9.072, n = 154 | |
| 18-OH-THA diabetic women | 119.7 ± 19.71, n = 17 | <0.0001 |
| 18-OH-THA control women | 56.15 ± 8.236, n = 159 | |
| THB diabetic men | 134.5 ± 14.65, n = 21 | 0.484 |
| THB control men | 159.5 ± 6.44, n = 155 | |
| THB diabetic women | 142 ± 22.47, n = 20 | 0.578 |
| THB control women | 113.3 ± 7.303, n = 161 | |
| TH-DOC diabetic men | 6.395 ± 0.9297, n = 21 | 0.289 |
| TH-DOC control men | 7.284 ± 0.4031, n = 155 | |
| TH-DOC diabetic women | 8.24 ± 2.714, n = 20 | 0.979 |
| TH-DOC control women | 6.848 ± 0.6151, n = 161 | |
| Glucocorticoid metabolites | ||
| THS diabetic men | 94.68 ± 9.324, n = 21 | 0.006 |
| THS control men | 65.58 ± 2.706, n = 155 | |
| THS diabetic women | 74.83 ± 7.069, n = 20 | 0.006 |
| THS control women | 51.13 ± 2.646, n = 161 | |
| 5α-THF diabetic men | 2047 ± 194.8, n = 21 | 0.002 |
| 5α-THF control men | 1390 ± 59.78, n = 154 | |
| 5α-THF diabetic women | 1614 ± 446.9, n = 20 | 0.0004 |
| 5α-THF control women | 627.8 ± 36.66, n = 159 | |
| 5β-THF diabetic men | 2500 ± 269.4, n = 21 | 0.013 |
| 5β-THF control men | 1695 ± 61.85, n = 154 | |
| 5β-THF diabetic women | 2302 ± 258, n = 20 | <0.0001 |
| 5β-THF control women | 1164 ± 58.92, n = 159 | |
| α-cortol diabetic men | 455 ± 39.45, n = 21 | 0.013 |
| α-cortol control men | 316.7 ± 10.17, n = 155 | |
| α-cortol diabetic women | 487.8 ± 73.75, n = 20 | <0.0001 |
| α-cortol control women | 216.3 ± 9.463, n = 161 | |
| cortisone diabetic men | 182.8 ± 18.4, n = 21 | 0.402 |
| cortisone control men | 173.8 ± 6.047, n = 155 | |
| cortisone diabetic women | 229.5 ± 34.34, n = 20 | 0.009 |
| cortisone control women | 144.5 ± 8.794, n = 161 | |
| cortisol diabetic men | 132.1 ± 21.42, n = 21 | 0.013 |
| cortisol control men | 156.9 ± 6.009, n = 155 | |
| cortisol diabetic women | 161 ± 27.08, n = 20 | 0.471 |
| cortisol control women | 126.6 ± 7.409, n = 161 | |
| β-cortol diabetic men | 511.3 ± 51.29, n = 21 | 0.769 |
| β-cortol control men | 509 ± 20.37, n = 155 | |
| β-cortol diabetic women | 651.6 ± 91.68, n = 20 | <0.0001 |
| β-cortol control women | 301.7 ± 16.81, n = 161 | |
| THE diabetic men | 4507 ± 536.6, n = 21 | 0.004 |
| THE control men | 2885 ± 110.9, n = 151 | |
| THE diabetic women | 3603 ± 420.0, n = 20 | <0.0001 |
| THE control women | 1953± 139.7, n = 159 | |
| α-cortolone diabetic men | 1592 ± 147.4, n = 20 | 0.009 |
| α-cortolone control men | 1120 ± 43.83, n = 153 | |
| α-cortolone diabetic women | 1538 ± 164.1, n = 20 | <0.0001 |
| α-cortolone control women | 783.5 ±32.76, n = 158 | |
| β-cortolone diabetic men | 755.9 ± 51.42, n = 20 | 0.113 |
| β-cortolone control men | 644.2 ± 22.62, n = 154 | |
| β-cortolone diabetic women | 811.9 ±80.59, n = 20 | <0.0001 |
| β-cortolone control women | 359.9 ±17.44, n = 161 |