Figure 5. Relationship Between the Spatial Overlap EMSI Results: PIZ and Distances to the Spike Onset, Maximum Spike Amplitude, and Seizure Core SEEG Reference Channels.

Linear regression analysis between AUC_PIZ and distances to the spike maximum amplitude (A), spike onset (B), and seizure core (C) reference contacts. Significant linear relationships between AUC_PIZ and distances were found for the spike maximum amplitude and spike onset but not for the seizure core. (D) Box plots with the median (black bars), interquartile range (color boxes), and extrema (dashed lines). Patients with good spatial overlap (AUC_PIZ >0.7) presented significant shorter distances to the spike maximum amplitude channel (Mann-Whitney U test, p = 0.04) compared with patients for whom the spatial overlap was poor (AUC_PIZ <0.7). No statistical differences were found between both groups when considering the distance to the spike onset and seizure core channels (p = 0.05 and p = 0.5, respectively). AUC = area under the receiver operating characteristic curve; EMSI = EEG/magnetoencephalography source imaging; PIZ = primary irritative zone; SEEG = stereo-EEG. *p < 0.05.