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. 2022 Jun 24;17(6):e0264651. doi: 10.1371/journal.pone.0264651

Fig 4. Breast cancer cells spiked in blood can be detected based on CCT2 staining using the CSS.

Fig 4

Representative images of (A) whole healthy human blood without spiked cancer cells processed through the CSS and stained for CCT2, and (B-C) Representative images of MDA-MB-231 (B) or T47D-CCT2 (C) cells spiked into human blood, processed through the CSS, and stained for CCT2. Light blue arrows: leukocyte that is CCT2 positive. Red arrows: cells with dim CK signal and CCT2 positive signal. Yellow arrows: leukocytes that have dim CCT2 signal. Dark blue arrow: doublet of spiked cancer cells with different CCT2 staining intensities. Grey arrows: cells with dim CCT2 signal. CK-FLU. This data is representative of ten experiments.