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. 2022 Jun 23;11:e79552. doi: 10.7554/eLife.79552

Figure 4. Conformational changes of the RF loop.

Figure 4.

(A) Comparison of RF loop structures in type A (pink and gray) and type B (yellow and blue) filaments. In type B filament, the RF loop partially occupies the active site that blocks nucleotide binding. (B) Comparison of RF loop structures between type B filament and Bacillus substilis PRPS (PDB ID: 1DKU). Residues in 1DKU number with the ’ symbol. (C) B factors are shown on the RF loop of type A and type B filament models. (D) Structural comparison shows that the Bacillus substilis PRPS (PDB ID: 1DKU) model, the RF loop in type A filament overlaps with ADP at allosteric site 1. Residues in 1DKU number with the ’ symbol.