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. 2022 Jun 8;31(11-12):322–333. doi: 10.1089/scd.2022.0004

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© Maria Espinosa Gonzalez et al., 2022; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License [CC-BY] (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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FIG. 3. — Th2 cytokines upregulate immunosuppressive M2 markers in BM myeloid precursors. CSF-1-primed BM cells were stimulated with 10 ng/mL of IL-4 (A), IL-13 (B), or IL-10 (C) instead of LPS. Expression of M2 surface markers CD163, CD204, CD206, and PD-L1 was determined by flow cytometry on day 6 of differentiation. Representative histograms of Th2 cytokine-induced M2 targets are presented. Numbers indicate percent of positive cells for each target. (D) Mean percent of positive cells ± SD and (E) mean MFI ( × 10³) ± SD for each M2 marker induced by IL-4, IL-13, or IL-10 in CSF-1-primed cells, as indicated by symbols. All analyses were reproduced three times.