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. 2022 Jun 8;12:906824. doi: 10.3389/fonc.2022.906824

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Copyright © 2022 Yu, Wang, Su, Pan, Tu, Zhao, Shen, Qiu, Liu, Luan, Wang, Meng and Shi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes in c-reactive protein (CRP) and interleukin-6 (IL-6) levels with the development of immune-related adverse events (irAEs). (A) Changes inn CRP, IL-6, and lymphocyte subsets at baseline, irAEs-onset, and irAEs-offset in patients with irAEs. (B) Comparison of CRP and IL-6 levels between baseline and irAEs onset in patients with different grades of irAEs. CRP, C-reactive protein; IL-6, interleukin-6; G1: grade 1; G2, grade 2; G3, grade 3; G4, grade 4; *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.000; ns, no statistical difference.