Table 4.
Performance of the radiomic model and integrated model for predicting large-volume LNM in the PTMC and CPTC subgroups.
| AUROC (95% CI) | AUPR (95% CI) | ACC (95% CI) | SEN (95% CI) | SPE (95% CI) | PPV (95% CI) | NPV (95% CI) | |
|---|---|---|---|---|---|---|---|
| PTMC subgroup (n = 114) | |||||||
| Integrated model | 0.901 (0.790–1) | 0.298 (0.261–0.335) | 96 (90–99) | 60 (15–95) | 97 (92–99) | 50 (12–88) | 98 (93–100) |
| Radiomic model | 0.875 (0.794–0.957) | 0.145 (0.131–0.159) | 87 (79–93) | 67 (22–96) | 88 (80–93) | 24 (7–50) | 98 (93–100) |
| Clinical model | 0.752 (0.494–1) | 0.016 (0.010–0.022) | 80 (71–87) | 60 (15–95) | 81 (72–88) | 12 (3–32) | 98 (92–100) |
| CPTC subgroup (n = 192) | |||||||
| Integrated model | 0.897 (0.825–0.970)∗ | 0.539 (0.496–0.582) | 92 (87–95) | 68 (46–85) | 95 (91–98) | 68 (46–85) | 95 (91–98) |
| Radiomic model | 0.877 (0.817–0.936)∗ | 0.463 (0.432–0.494) | 83 (77–88) | 72 (51–88) | 84 (78–90) | 41 (26–57) | 95 (90–98) |
| Clinical model | 0.704 (0.593–0.814) | 0.292 (0.245–0.339) | 77 (70–83) | 44 (24–65) | 82 (75–88) | 27 (14–43) | 91 (85–95) |
∗ Significantly different (Delong test) p < 0.05 from clinical model. AUPR, area under the precision-recall curve; AUROC, area under the receiver operator characteristic curve; ACC, accuracy; CI, confidence interval; CPTC, conventional papillary thyroid cancer; NPV, negative predictive value; PPV, positive predictive value; PTMC, papillary thyroid microcarcinoma; SEN, sensitivity; SPE, specificity.