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. 2022 May 7;23(3-4):129–140. doi: 10.1038/s41435-022-00172-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A HLA-related gene expression was examined for the high-risk subset of Cohort 1 by the R2. High-level expression of classical HLA-Class II genes (HLA-DRA, HLA-DRB1, HLA-DPA1, HLA-DPB1) was detected in high-risk neuroblastoma tissues. A similar trend was observed in Cohort 2 (see Fig. S1). B (a) HLA-DRA expression was significantly correlated with HLA-DRB1 expression in high-risk neuroblastomas of Cohort 1. (b) Combination of high HLA-DRA and HLA-DRB1 expressions was significantly associated with prolonged survival of the high-risk patients of Cohort 1. C (a) HLA-DPA1 expression was significantly correlated with HLA-DPB1 expression in high-risk neuroblastomas of Cohort 1. (b) Combination of high HLA-DPA1 and HLA-DPB1 expressions was significantly associated with prolonged survival of the high-risk patients of Cohort 1. The expression unit of genes in Cohort 1 is Reads Per Million (RPM). Average expression of each gene was shown as Log2 of RPM. Error bars indicate standard deviations.