Fig. 1.

Tumor hypoxia patterns in UM. (A) The distribution of hypoxia scores for 20 types of tumors, sorted by median values. The interquartile range (IQR) was calculated to measure the intertumoral variability of hypoxia for each type of tumor. The violin plot depicts the distribution of hypoxia scores using density curves. The boxes show the median ± 1 quartile. Whiskers extend 1.5 times the IQR. (B) Boxplot showing differences of tumor hypoxia pattern between subgroups stratified by clinicopathological characteristics including clinical stages, T stages, and metastasis status (Mann-Whitney U test). (C) Heatmap showing gene expression profiles for Buffa’s hypoxia metagene signature. (D) Kaplan-Meier curves of overall and disease-free survival for high and low hypoxic tumors (Log-rank test). The number of cases and events in a subgroup are shown in the plots.