Fig. 2.

The multidimensional molecular features of tumor hypoxia phenotype. (A) Scatter plot showing the association between tumor hypoxia and genome instability (Spearman’s rho). (B) Boxplot of hypoxia scores among four clusters previously defined (Kruskal-Wallis test). (C) Associations of SNVs and CNVs with tumor hypoxia in UM. (D) Hypoxia-associated multidimensional molecular signatures (Spearman’s rho). Results are shown for the top ten positively and top ten negatively correlated features, according to adjusted P-value. PGA, the percentage of the genome altered by copy-number aberrations; SNV, single-nucleotide variant; CNV, copy number variation.