Fig. 3.

Functional insights of distinct hypoxic patterns in UM tumors. (A) Heatmap representation of differential gene expression between hypoxic and normoxic tumors. (B) Functional enrichment network of GO terms of hypoxia-related genes. (C) Top ten most significant KEGG pathways by enrichment analyses. (D) Volcano plot for enriched (red) and depleted (blue) immune cell subsets in the hypoxic tumors compared with the normoxic tumors. (E) Gene set enrichment analysis plot of activated CD8 T cell, activated B cell, type 1 T helper cell, activated CD4 T cell, regulatory T cell, and myeloid-derived suppressor cell. The vertical-colored short lines in the middle panel of the GSEA plot highlight markers of six enriched immune cell types in the ordered gene list. NES, normalized enrichment score. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)