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Effects of hypoxia on the tumor metabolic microenvironment. (A) Heatmap of pathway-level transcriptional activity profiles for 86 metabolic pathways from the KEGG database. A two-sided P < 0.05 is considered a statistically significant difference using limma. (B) The distribution of dysregulated pathways in ten metabolic subcategories. These dysregulated pathways encompass most of the metabolic subcategories except energy metabolic pathways.
