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. 2022 Jun 16;20:3182–3194. doi: 10.1016/j.csbj.2022.06.034

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© 2022 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 6 — Effects of hypoxia and immune on patient prognosis. (A) Forest plot depicting the impact of immune cell compositions on patients’ survival outcomes using the univariate Cox regression analysis. HR refers to the hazard ratio for subjects with a high level of immune cell composition compared with other subjects. (B-F) Combining hypoxic patterns and immune cell compositions provides more delicate risk stratification for UM subjects in the TCGA cohort (log-rank test). (B) naïve B cell, (C) resting memory CD4 T cell, (D) resting dendritic cell, (E) CD8 T cell, and (F) M0 macrophage. The number of cases and events in a subgroup are shown in the plots. HR, hazard ratio; CI, confidence interval; HS(L), low hypoxia score; HS(H), high hypoxia score; IS(L), low immune score; IS(H), high immune score.