| A population pharmacokinetic model was developed to describe the tacrolimus concentrations in peripheral blood mononuclear cells (PBMCs) using whole-blood concentrations. |
| Lean body weight and haematocrit values influenced the PBMC:whole blood ratio. |
| If more information is known about target levels for PBMC tacrolimus, this model can be used to individualize tacrolimus dosing based on predicted intracellular concentrations. |
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